Реакция #574069

Уравнение реакции

HCl

water

2-(4-aminophenoxy)-2-methylpropionic acid

3,5-dichlorophenyl isocyanate

→

2-(4-(3,5-Dichlorophenylureido)phenoxy)-2-methylpropionic acid

Растворители

pyridine

Условия реакции

Обработка

1. 1
   ФильтрацияThe precipitate was filtered
2. 2
   Промывкаwashed several times with cold water
3. 3
   Другоеdried
4. 4
   ДругоеRecrystallization from aqueous acetone
5. 5
   Другоеgave small plates 1.81 g (94%) MP 182°-184°

Методика

To a stirring solution of 4.95 g (0.025 mole) of 2-(4-aminophenoxy)-2-methylpropionic acid in 50 ml dry pyridine, 4.95 g (0.025 mole) of 3,5-dichlorophenyl isocyanate were added. After 1 hour stirring at room temperature, 150 ml water was added and the mixture was acidified with concentrated HCl. The precipitate was filtered, washed several times with cold water and dried. Recrystallization from aqueous acetone gave small plates 1.81 g (94%) MP 182°-184°.

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