Реакция #57119

ord-fdd39cd513c047619cf99a7e0873ef74

Уравнение реакции

CC(c1ccc2ccccc2c1)C1(O)CCCCC1N1CC[C@@H](N)C1.Cl.Cl
2-[(3R)-3-aminopyrrolidin-1-yl]-1-(2-naphthyl)ethylcyclohexanol dihydrochloride
CC(C)(C)OC(=O)N[C@@H]1CCN(C(=O)C(c2ccc3ccccc3c2)C2(O)CCCCC2)C1
tert-butyl {(3R)-1-[(1-hydroxycyclohexyl)(2-naphthyl)acetyl]pyrrolidin-3-yl}carbamate
→
Cl.Cl.N[C@@H]1CCN(CC(c2ccc3ccccc3c2)C2(O)CCCCC2)C1
1-[2-[(3R)-3-aminopyrrolidin-1-yl]-1-(2-naphthyl)ethyl]cyclohexanol Dihydrochloride

Реактанты

CC(c1ccc2ccccc2c1)C1(O)CCCCC1N1CC[C@@H](N)C1.Cl.Cl
2-[(3R)-3-aminopyrrolidin-1-yl]-1-(2-naphthyl)ethylcyclohexanol dihydrochloride
CC(C)(C)OC(=O)N[C@@H]1CCN(C(=O)C(c2ccc3ccccc3c2)C2(O)CCCCC2)C1
tert-butyl {(3R)-1-[(1-hydroxycyclohexyl)(2-naphthyl)acetyl]pyrrolidin-3-yl}carbamate

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

In an analogous manner to Example 1, step 2, 1-[2-[(3R)-3-aminopyrrolidin-1-yl]-1-(2-naphthyl)ethylcyclohexanol dihydrochloride was prepared from tert-butyl {(3R)-1-[(1-hydroxycyclohexyl)(2-naphthyl)acetyl]pyrrolidin-3-yl}carbamate. MS (ESI) m/z 339; HRMS: calcd for C22H30N2O+H+, 339.24309; found (ESI, [M+H]+), 339.243.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07419980B2uspto-grants-2008_09