Реакция #56915

Уравнение реакции

4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine

2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol

hexan-1-ol

→

4-(5-bromo-2-hexyloxy-phenyl)-6-chloro-pyrimidin-2-ylamine

Выход 47.0%

Условия реакции

Методика

Following the method described in Example 135 for the synthesis of 4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol and hexan-1-ol provided 4-(5-bromo-2-hexyloxy-phenyl)-6-chloro-pyrimidin-2-ylamine (47% yield).

Источник