Реакция #56913

Уравнение реакции

4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine

2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol

→

4-[5-bromo-2-(2-methoxy-ethoxy)-phenyl)-6-chloro-pyrimidin-2-ylamine

Выход 42.0%

Растворители

2-methoxy-ethanol

Условия реакции

Методика

Following the method described in Example 135 for the synthesis of 4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol and 2-methoxy-ethanol provided 4-[5-bromo-2-(2-methoxy-ethoxy)-phenyl)-6-chloro-pyrimidin-2-ylamine (42% yield).

Источник