Реакция #56907

Уравнение реакции

2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol

1-propanol

triphenylphosphine

diethyl azodicarboxylate

→

4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine

Выход 52.5%

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   Концентрированиеthe mixture was concentrated under reduced pressure
2. 2
   ДругоеThe residue was purified by flash chromatography on silica gel eluting with ethyl acetate-hexane (1:6)

Методика

To the stirred solution of 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol (0.060 g, 0.20 mmol), 1-propanol (0.036 g, 0.60 mmol), and triphenylphosphine (0.157 g, 0.60 mmol) in tetrahydrofuran (5.0 ml) was added diethyl azodicarboxylate (0.104 g, 0.60 mmol). After stirring for 16 hours, the mixture was concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel eluting with ethyl acetate-hexane (1:6) to provide 4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine (0.036 g, 52% yield) as a white powder.

Источник