Реакция #56879

ord-ebc24cc6a85a45a39f40bed4fa88c9c3

Уравнение реакции

Cc1ccc(Br)cc1-c1cc(Cl)nc(N)n1
4-(5-bromo-2-methyl-phenyl)-6-chloro-pyrimidin-2-ylamine
Nc1ccc(Br)cc1
4-bromo-phenylamine
Cc1ccc(Br)cc1-c1cc(Nc2ccc(Br)cc2)nc(N)n1
title compound
Выход 91.0%
Cc1ccc(Br)cc1-c1cc(Nc2ccc(Br)cc2)nc(N)n1
6-(5-Bromo-2-methyl-phenyl)-N*4*-(4-bromo-phenyl)-pyrimidine-2,4-diamine
Выход 91.0%

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

Following the method described in Example 26, 4-(5-bromo-2-methyl-phenyl)-6-chloro-pyrimidin-2-ylamine and 4-bromo-phenylamine provided the title compound (91% yield). 1H NMR (DMSO-d6) δ 2.34 (s, 3H, CH3), 6.37 (s, 1H, Ar), 7.40 (d, 1H, J=8.9 Hz, Ar), 7.59 (d, 2H, J=8.7 Hz, Ar), 7.70-7.71 (m, 2H, Ar), 7.82-7.84 (m, 2H, Ar), 10.89 (br s, 1H, NH).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07419984B2uspto-grants-2008_09