Реакция #567622

Уравнение реакции

2-chloro-3-methyl-5-(3-methylphenyl)-6-(4-pyridyl)-4(3H)-pyrimidinone

3-phenyl-2,2-dimethyl-1,3-propanediamine

→

2-((-3-Amino-2,2-dimethyl-3-phenylpropyl)-amino)-3-methyl-5-(3-methylphenyl)-6-(4-pyridyl)-4(3H)-pyrimidinone hydrochloride

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was evaporated
2. 2
   Другоеthe crude product purified by column chromatography on silica gel

Методика

A solution of 2-chloro-3-methyl-5-(3-methylphenyl)-6-(4-pyridyl)-4(3H)-pyrimidinone (228 mg, 0.73 mmol) and 3-phenyl-2,2-dimethyl-1,3-propanediamine (178 mg, 1 mmol) (prepared according to: W. Ten Hoeve and H. Wynberg, Synth. Commun. 24 (15), 2215-2221, 1994) in ethanol (4 ml) was stirred at room temperature for 16 h. The solvent was evaporated and the crude product purified by column chromatography on silica gel. MS (m/z): 454 (M+H)+; C28H31N5O requir. 453.6 (free base).

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