Реакция #5674

Уравнение реакции

oxazolidinone

diethyl bromomalonate

potassium carbonate

acetone

→

1,3-benzodioxole-2,2-dicarboxylic acid, diethyl ester

Условия реакции

Обработка

1. 1
   Фильтрацияfiltered
2. 2
   Промывкаwashed with acetone
3. 3
   Другоеevaporated to a brown oil
4. 4
   ДругоеThe oil is purified by flash chromatography
5. 5
   Промывкаeluting with 5 percent acetone in toluene
6. 6
   Другоеevaporated

Методика

A mixture of 240 mg of the above oxazolidinone, 234 mg of diethyl bromomalonate, 450 mg of anhydrous potassium carbonate and 10 ml of acetone is stirred overnight, filtered, washed with acetone and evaporated to a brown oil. The oil is purified by flash chromatography, eluting with 5 percent acetone in toluene. The pure fractions are combined and evaporated giving 237 mg of (R,R)-5-(3-chlorophenyl)-2-oxo-3-oxazolidinyl)propyl)-1,3-benzodioxole-2,2-dicarboxylic acid, diethyl ester as a colorless oil.

Источник