Реакция #56590

Уравнение реакции

2-(6-chlorohexyloxy)tetrahydropyrane

hydroquinone

potassiumcarbonate

potassiumiodide

→

product

Выход 82.5%

4-(6-(2-Tetrahydropyranyl)oxyhexyloxy)phenol

Выход 82.5%

Растворители

dimethylsulfoxide

water

Условия реакции

Обработка

1. 1
   Другоеto react for 4 days at 80° C
2. 2
   Экстракцияextracted with ether
3. 3
   СушкаThe organic phase was then dried over sodium sulphate
4. 4
   Фильтрацияfiltered
5. 5
   Концентрированиеconcentrated to dryness

Методика

A mixture of 10 g of 2-(6-chlorohexyloxy)tetrahydropyrane, 25 g of hydroquinone, 31 g of potassiumcarbonate, 0.752 g of potassiumiodide and 250 ml of dimethylsulfoxide was allowed to react for 4 days at 80° C. Subsequently, the reaction mixture was cooled to room temperature and after addition of water extracted with ether. The organic phase was then dried over sodium sulphate, filtered and concentrated to dryness. Chromatography on silica with 10% ethylacetate in toluene gave 11 g of product as a yellowish oil.

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