Реакция #5656

Уравнение реакции

NaH

(S)-1-(2-furyl)-1-pentanol

bromoacetic acid

→

crude product

4-(2-furyl)-3-oxaoctanoic acid

Растворители

THF

THF

THF

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added dropwise
2. 2
   workup.ADDITIONAfter the addition
3. 3
   Температураbefore cautiously heating
4. 4
   Температураto reflux for 1 h
5. 5
   ТемператураThe mixture was refluxed 2 days
6. 6
   Температураbefore cooling
7. 7
   ПромывкаThe aqueous was washed with ether
8. 8
   Экстракцияextracted with ether
9. 9
   ПромывкаThe combined organic extracts were washed with brine
10. 10
    Сушкаdried over MgSO4
11. 11
    Другоеevaporated

Методика

NaH (16.3 g, 680.9 mmol) and freshly distilled THF (170 mL) Were stirred at room temperature as (S)-1-(2-furyl)-1-pentanol ([α]25D -17.2°, 30.0 g, 46.0 mmol) in THF (170 mL) was added dropwise. After the addition was complete, the mixture was stirred for 15 m before cautiously heating to reflux for 1 h. The mixture was cooled to 0° C. before adding dropwise a solution of bromoacetic acid (27.3 g, 196.5 mmol) in THF (40 mL). The mixture was refluxed 2 days before cooling and carefully pouring into 600 mL ice water. The aqueous was washed with ether and acidified with HCl to pH 4, and extracted with ether. The combined organic extracts were washed with brine, dried over MgSO4, and evaporated to give a quantitative yield of crude product which was used in the next step without further purification.

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