Реакция #565485

Уравнение реакции

product

Methyl [(1-methyl-2-propynyl)oxy]acetate

methanol

→

title compound

Methyl (1-methyl-2-oxopropoxy)acetate

Условия реакции

Обработка

1. 1
   Температураheated
2. 2
   Температураto reflux for 1 hour
3. 3
   Концентрированиеconcentrated to approximately 100 mL total volume
4. 4
   workup.ADDITIONtreated with 1M HCl (100 mL)
5. 5
   Экстракцияextracted with dichloromethane (3×, 100 mL)
6. 6
   ЭкстракцияThe extractions
7. 7
   Сушкаdried (MgSO4)
8. 8
   Фильтрацияfiltered
9. 9
   Концентрированиеconcentrated

Методика

The product from Example 84A (20 g, 0.14 mol) in methanol (700 mL) was treated with mercury(II) acetate (4.6 g, 0.014 mol), heated to reflux for 1 hour, concentrated to approximately 100 mL total volume, treated with 1M HCl (100 mL) and extracted with dichloromethane (3×, 100 mL). The extractions were combined, dried (MgSO4), filtered and concentrated to provide the title compound.

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