Реакция #56537

Уравнение реакции

2-cyano-2-(2,4-dichlorophenyl)decan-1-ol

methane sulfonyl chloride

triethylamine

→

2-cyano-2-(2,4-dichlorophenyl)decyl methane sulfonate

Растворители

benzene

Условия реакции

Обработка

1. 1
   workup.ADDITIONis added dropwise at 10° C.
2. 2
   Температураheated on a steam bath for another 30 minutes
3. 3
   ДругоеThe precipitate formed
4. 4
   Фильтрацияis filtered
5. 5
   Промывкаthe filtrate is washed with dilute hydrochloric acid, water, saturated sodium bicarbonate solution, saturated sodium chloride solution
6. 6
   Сушкаdried over magnesium sulfate
7. 7
   ДругоеThe solvent is evaporated
8. 8
   Другоеto give 41.3 g

Методика

To a mixture of 2-cyano-2-(2,4-dichlorophenyl)decan-1-ol (40 g., 0.12 mole) and methane sulfonyl chloride (15.3 g., 0.13 mole) in 2 liters of benzene is added dropwise at 10° C., 14.8 g., (0.14 mole) of triethylamine. The reaction mixture is stirred at room temperature for 30 minutes and then heated on a steam bath for another 30 minutes. The precipitate formed is filtered and the filtrate is washed with dilute hydrochloric acid, water, saturated sodium bicarbonate solution, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 41.3 g. of product, which is identified by nmr.

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