Реакция #56536

Уравнение реакции

α-n-octyl-2,4-dichlorobenzyl cyanide

pyridine

paraformaldehyde

benzyl triethylammonium hydroxide

→

2-cyano-2-(2,4-dichlorophenyl)decan-1-ol

Растворители

water

Условия реакции

Обработка

1. 1
   workup.ADDITIONis added 1 ml
2. 2
   Экстракцияextracted with ether
3. 3
   ПромывкаThe combined ether extracts are washed with water, saturated sodium chloride solution
4. 4
   Сушкаdried over magnesium sulfate
5. 5
   ДругоеThe solvent is evaporated
6. 6
   Другоеto give 40 g

Методика

To an ice cold stirred solution of α-n-octyl-2,4-dichlorobenzyl cyanide (40 g., 0.14 mole) in 250 ml. of pyridine containing a suspension of paraformaldehyde (21 g., 0.7 mole) is added 1 ml. of benzyl triethylammonium hydroxide. The mixture is stirred under nitrogen at room temperature for 72 hours. The reaction mixture is poured into 2 liters of water and extracted with ether. The combined ether extracts are washed with water, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 40 g. of a thick oil.

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