Реакция #56534

Уравнение реакции

2-cyano-2-(2,4-dichlorophenyl)hexyl methane sulfonate

imidazole

N,N-dimethylformamide

→

expected product

Выход 68.0%

1-[2-cyano-2-(2,4-dichlorophenyl)hexyl]imidazole hydrochloride

Выход 68.0%

Растворители

water

Условия реакции

Обработка

1. 1
   Температураis heated
2. 2
   Экстракцияextracted with ether
3. 3
   СушкаThe combined ether extracts are dried over magnesium sulfate
4. 4
   ФильтрацияThe drying agent is filtered and into the ethereal solution
5. 5
   Другоеis bubbled dry hydrogen chloride gas
6. 6
   ДругоеThe white solid which precipitates
7. 7
   Другоеis collected
8. 8
   Другоеdried
9. 9
   Другоеto give 70.4 g

Методика

A mixture of 2-cyano-2-(2,4-dichlorophenyl)hexyl methane sulfonate (100 g., 0.29 mole), imidazole (100 g., 1.5 mole) and N,N-dimethylformamide (5 ml.) is heated with stirring at 135° C. overnight. The reaction mixture is poured into water and extracted with ether. The combined ether extracts are dried over magnesium sulfate. The drying agent is filtered and into the ethereal solution is bubbled dry hydrogen chloride gas. The white solid which precipitates is collected and dried to give 70.4 g. (68%) of the expected product, which is identified by nmr.

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