Реакция #5610

Уравнение реакции

5-benzyloxy-2-vinyl-4-pyridone

pyrrolidine

→

5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone

Растворители

tetrahydrofuran

diisopropyl ether

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураrefluxed for an hour
3. 3
   ТемператураThe mixture was cooled
4. 4
   Фильтрацияthe resulting precipitate was collected by filtration
5. 5
   Промывкаwashed with diisopropyl ether
6. 6
   Другоеair-dried at ambient temperature

Методика

A mixture of 5-benzyloxy-2-vinyl-4-pyridone (2.90 g) and pyrrolidine (5.33 ml) was heated and refluxed for an hour. The mixture was cooled and diluted with tetrahydrofuran (20 ml) and diisopropyl ether (80 ml). After being stirred for an hour at ambient temperature, the resulting precipitate was collected by filtration, washed with diisopropyl ether and air-dried at ambient temperature to give 5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone (3.79 g).

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