Реакция #560806

Уравнение реакции

2-fluoropyridin-3-ylboronic acid

4-bromo-2-(trifluoromethyl)pyridine

sodium carbonate

→

title compound

2-FLUORO-2′-(TRIFLUOROMETHYL)-3,4′-BIPYRIDINE

Растворители

H2O

DME

ethanol

water

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling to room temperature
2. 2
   Экстракцияextracted with CH2Cl2 (3×)
3. 3
   СушкаThe combined organics were dried over Na2SO4
4. 4
   Фильтрацияfiltered
5. 5
   Концентрированиеconcentrated
6. 6
   ДругоеThe residue was purified

Методика

A mixture of 2-fluoropyridin-3-ylboronic acid (0.748 g, 5.3 mmol), 4-bromo-2-(trifluoromethyl)pyridine (1.00 g, 4.4 mmol), Pd(PPh3)2Cl2 (0.155 g, 0.22 mmol) and sodium carbonate (0.797 g, 13.3 mmol) in DME (6.5 mL), ethanol (1.9 mL) and water (0.47 mL) was heated to 95° C. for 2 h. After cooling to room temperature, the mixture was diluted with H2O and extracted with CH2Cl2 (3×). The combined organics were dried over Na2SO4, filtered and concentrated. The residue was purified using column chromatography (EtOAc/Hexanes=0→20%) to give the title compound. MS (ESI, pos. ion) m/z: 243 (M+1).

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