Реакция #5608

Уравнение реакции

2-chloromethyl-5-benzyloxy-4-pyridone

tetrahydrofuran

dimethylamine hydrochloride

sodium hydroxide

→

5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone

Выход 96.7%

Растворители

water

Условия реакции

Обработка

1. 1
   Концентрированиеthe mixture was concentrated under reduced pressure to dryness
2. 2
   workup.DISSOLUTIONThe residue was dissolved in methanol
3. 3
   Фильтрацияthe insoluble material was filtered off
4. 4
   ДругоеThe filtrate was evaporated in vacuo

Методика

To a mixture of 2-chloromethyl-5-benzyloxy-4-pyridone (1.0 g), tetrahydrofuran (10 ml) and water (10 ml) were added dimethylamine hydrochloride (1.31 g) and sodium hydroxide (0.64 g). After being stirred for 1.5 hours, the mixture was concentrated under reduced pressure to dryness. The residue was dissolved in methanol and the insoluble material was filtered off. The filtrate was evaporated in vacuo to give 5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone (1.0 g) as a powder.

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