Реакция #56041

Уравнение реакции

5-cyano-6-methyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester

selenium dioxide

→

5-Cyano-6-formyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester

Растворители

dioxane

Условия реакции

Обработка

1. 1
   ФильтрацияAfter this time the selenium is filtered off
2. 2
   Другоеthe solvent removed in vacuo
3. 3
   ДругоеThe resulting oily residue is crystallized with ether

Методика

26.1 g of 5-cyano-6-methyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester (0.1 mol) and 13 g of selenium dioxide are refluxed together in dioxane for 24 hours. After this time the selenium is filtered off and the solvent removed in vacuo. The resulting oily residue is crystallized with ether. Yield 19 g (69%); m.p. 37°-38° C. (methanol).

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