Реакция #5604

Уравнение реакции

toluene

pyrrolidine

ethyl bromoacetate

→

ETHYL 1-PYRROLIDINEACETATE

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   Температураmaintaining the temperature below 30° C
2. 2
   Другоеto precipitate pyrrolidinium bromide, which
3. 3
   Другоеwas separated by filtration
4. 4
   ДругоеThe filtrate was evaporated under vacuum
5. 5
   Другоеto provide a residue of about 241 g of ethyl 1-pyrrolinidineacetate

Методика

To an ice bath-cooled solution of 213.4 g (3 mol) of pyrrolidine in 450 mL of tetrahydrofuran was added dropwise over about 2 hours 250.5 g (1.5 mol) of ethyl bromoacetate, maintaining the temperature below 30° C. To this solution was added 150 mL of toluene to precipitate pyrrolidinium bromide, which was separated by filtration. The filtrate was evaporated under vacuum to provide a residue of about 241 g of ethyl 1-pyrrolinidineacetate.

Источник