Реакция #56038

Уравнение реакции

5-cyano-6-methyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester

selenium dioxide

→

5-Cyano-6-formyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester

Растворители

ether

Условия реакции

Обработка

1. 1
   workup.DISTILLATIONThe solvent is distilled off in vacuo
2. 2
   Другоеthe oily residue crystallized with diethyl ether

Методика

27 g of 5-cyano-6-methyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester (0.1 mol) and 12.2 g selenium dioxide (0.11 mol) are refluxed together in diethyleneglycoldimethyl ether with stirring for 1.5 hours. The solvent is distilled off in vacuo and the oily residue crystallized with diethyl ether. Yield 19 g (66%); m.p. 62°-64° C. (ether).

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