Реакция #56010

Уравнение реакции

malonic acid

diethanol amine

benzaldehyde

→

Bis-(hydroxyethyl)amino benzyl malonic acid

Растворители

methanol

Условия реакции

Обработка

1. 1
   Другоеequipped with a stirrer
2. 2
   Температураreflux condenser
3. 3
   Другоеthe reaction commenced
4. 4
   ТемператураAfter refluxing the reaction mixture for 1 hour
5. 5
   Другоеthe methanol was removed from the reaction mixture
6. 6
   Температураheating to a temperature of about 50° C
7. 7
   Другоеthen was triturated in acetone
8. 8
   Другоеthe resulting acid isolated by filtration

Методика

Bis-(hydroxyethyl)amino benzyl malonic acid was prepared conventionally in a flask equipped with a stirrer and reflux condenser by first charging 0.1 mol of malonic acid, 0.1 mol of diethanol amine and 100 cc methanol. The contents were warmed to a temperature of about 20° C. and then 0.1 mol benzaldehyde were added to the flask and the reaction commenced. After refluxing the reaction mixture for 1 hour, the methanol was removed from the reaction mixture by coupling the flask to a vacuum source and heating to a temperature of about 50° C. The residue remaining in the flask then was triturated in acetone and the resulting acid isolated by filtration.

Источник