Реакция #55990

Уравнение реакции

(6-benzoyl-2-pyridyl)methanol

potassium hydroxide

hydrazine

→

(6-benzyl-2-pyridyl)methanol

Растворители

triethylene glycol

Условия реакции

Обработка

1. 1
   Температураis refluxed for 1.5 hours
2. 2
   Другоеthe water and excess hydrazine are removed by a takeoff condenser until the temperature
3. 3
   Другоеrises to 195°-200°
4. 4
   Температураthe solution is cooled
5. 5
   workup.ADDITIONpoured into ice and water (50 ml)
6. 6
   Экстракцияextracted with ether (3×20 ml)
7. 7
   ПромывкаThe combined ether layers are washed with water (3×20 ml), brine (10 ml)
8. 8
   Сушкаdried over calcium sulfate
9. 9
   ДругоеRemoval of solvents

Методика

A mixture of (6-benzoyl-2-pyridyl)methanol (1.5 g, 7 mmol), potassium hydroxide (1.3 g, 23 mmol) and hydrazine 85% (1 ml, 25 mmol) in triethylene glycol (10 ml) is refluxed for 1.5 hours, and then the water and excess hydrazine are removed by a takeoff condenser until the temperature rises to 195°-200°. After 4 hours at 195°-200°, the solution is cooled, poured into ice and water (50 ml) and extracted with ether (3×20 ml). The combined ether layers are washed with water (3×20 ml), brine (10 ml) and dried over calcium sulfate. Removal of solvents gives (6-benzyl-2-pyridyl)methanol.

Источник