Реакция #55980

Уравнение реакции

phosphorus tribromide

(6-phenoxy-2-pyridyl)methanol

phosphorus tribromide

→

(6-phenoxy-2-pyridyl)methyl bromide

Растворители

ether

Условия реакции

Обработка

1. 1
   ТемператураThe solution is refluxed for 1 hour
2. 2
   Температураrefluxing
3. 3
   Другоеresulting solid
4. 4
   Фильтрацияis filtered
5. 5
   Промывкаwashed with ether

Методика

To 8.45 mmol of (6-phenoxy-2-pyridyl)methanol in 75 ml ether is added, at -10°, 12.7 mmol of phosphorus tribromide. The solution is refluxed for 1 hour, after which approximately 1 ml of phosphorus tribromide is added and refluxing is continued for 2 hours. The reaction mixture is cooled to RT and resulting solid is filtered and washed with ether to yield the hydrogen bromide salt of (6-phenoxy-2-pyridyl)methyl bromide.

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