Реакция #55799

Уравнение реакции

2-chloromethylpyrimidine

ethylenediamine

N-(2-pyrimidylmethyl)ethylenediamine

methyl isothiocyanate

→

title compound

N-Cyano-N'-methyl-N"-[2-(2-pyrimidylmethylamino)ethyl]-guanidine

Условия реакции

Обработка

1. 1
   Другоеgives
2. 2
   Концентрированиеafter concentrating
3. 3
   ДругоеThis thiourea is reacted with lead cyanamide by the procedure of Examples 3(b)

Методика

Reaction of 2-chloromethylpyrimidine with ethylenediamine by the procedure of Example 34 and reaction of the resulting N-(2-pyrimidylmethyl)ethylenediamine with methyl isothiocyanate by the procedure of Example 3(b) gives, after concentrating and chromatographing, N-methyl-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea. This thiourea is reacted with lead cyanamide by the procedure of Examples 3(b) to give the title compound.

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