Реакция #5569

Уравнение реакции

5-mercaptoimidazo[1,2-a]pyridine

2-[2-(bromo)ethyl]isoindolin-1-one

triethylamine

→

desired product

Выход 77.0%

5-[2-(isoindolin-1-one-2-yl)ethylthio]imidazo[1,2-a]pyridine

Выход 77.0%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураheated
2. 2
   Температураat reflux for 2 hours
3. 3
   workup.DISTILLATIONAfter the solvent was distilled off
4. 4
   workup.ADDITIONchloroform was added to the residue which
5. 5
   Промывкаwas washed with water
6. 6
   Сушкаdried over anhydrous magnesium sulfate
7. 7
   workup.DISTILLATIONAfter the solvent was distilled off
8. 8
   Другоеthe residue was purified by column chromatography [eluent: ethyl acetate/ethanol (15:1)]

Методика

To a suspension of 5-mercaptoimidazo[1,2-a]pyridine (150 mg, 1 mmole) and 2-[2-(bromo)ethyl]isoindolin-1-one (240 mg, 1 mmole) in ethanol (15 ml) was added triethylamine (0.21 ml, 1.5 mmoles) and the mixture Was stirred at room temperature for 12 hours and heated at reflux for 2 hours. After the solvent was distilled off, chloroform was added to the residue which was washed with water and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was purified by column chromatography [eluent: ethyl acetate/ethanol (15:1)] to obtain 238 mg of the desired product (77.0%, light brown solid).

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