Реакция #55502

Уравнение реакции

ethanol

2,4-diamino-6-chloropyrimidine

ethanol

sodium hydroxide

3-chloro-perbenzoic acid

→

2,4-diamino-6-chloropyrimidine-3-oxide

Растворители

water

Условия реакции

Обработка

1. 1
   Другоеat 35° C
2. 2
   workup.WAITleft
3. 3
   workup.WAITto stand at 5° C. overnight
4. 4
   ФильтрацияThe solid material is filtered off
5. 5
   Другоеrecrystallized from ethanol, there

Методика

75 g. of 2,4-diamino-6-chloropyrimidine are dissolved in 1500 ml. of ethanol at 35° C. The solution is cooled to -10° C. and a solution of 100 g. of 3-chloro-perbenzoic acid in 500 ml. of ethanol is slowly added dropwise in the course of 1 hour. The suspension is subsequently stirred at -10° C. for 7 hours and left to stand at 5° C. overnight. The suspension is neutralized with 24 g. of sodium hydroxide in 100 ml. of water. The solid material is filtered off and recrystallized from ethanol, there being obtained pure 2,4-diamino-6-chloropyrimidine-3-oxide.

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