Реакция #554613

Уравнение реакции

Ethyl 6-phenyl-3-(3-ethoxy-3-oxopropyl)-1H-indole-2-carboxylate

lithium hydroxide trihydrate

→

3-(2-Carboxyethyl)-6-phenyl-1H-indole-2-carboxylic acid

Выход 95.0%

Растворители

tetrahydrofurane

water

THF

Условия реакции

Обработка

1. 1
   workup.STIRRINGto stir at rt for 24 h
2. 2
   Другоеwas removed under reduced pressure
3. 3
   Экстракцияthe product was extracted with diethyl ether (3×25 ml)
4. 4
   СушкаThe organic layers were dried over magnesium sulfate
5. 5
   Фильтрацияfiltered
6. 6
   Другоеevaporated to dryness
7. 7
   Другоеto yield a light-beige-colored solid in 95-100% yield

Методика

Ethyl 6-phenyl-3-(3-ethoxy-3-oxopropyl)-1H-indole-2-carboxylate (3.65 g, 10 mmol) was dissolved in 25 ml tetrahydrofurane (THF) with stirring at rt. Then a solution of 1.26 g of lithium hydroxide trihydrate (3 equiv.) in 25 ml water was added and the resulting mixture was let to stir at rt for 24 h. After completion of the reaction THF was removed under reduced pressure and the pH was adjusted to 4-5, and the product was extracted with diethyl ether (3×25 ml). The organic layers were dried over magnesium sulfate, filtered, and evaporated to dryness to yield a light-beige-colored solid in 95-100% yield. mp. 238-239° C. 1H-NMR (DMSO-d6) δ 2.54 (m, 2H, 2′-H); 3.28 (m, 2H, 1′-H); 7.35 (m, 2H, 4-H, 5-H); 7.46 (m, 2H, 2″-H, 6″-H); 7.60 (dd, 1H, 4″-H); 7.63 (m, 2H, 3″-H, 5″-H); 7.75 (dd, 1H, 7-H); 11.55 (s, 1H, NH); 12.50 (b, 2H, 2CO2H). 13C-NMR (DMSO-d6) δ 20.1 (C2′); 35.3 (C1′); 110.2 (C-7); 119.2 (C-5), 121.1 (C-4); 121.4 (C-3); 124.8 (C-3a); 126.6 (C-2); 127.0 (C-3″, C-5″); 127.2 (C-4″); 129.1 (C-3″, C-6″); 136.8 (C-7a); 137.2 (C-6); 141.3 (C-1″); 163.1 (2′-CO2H); 174.1 (2-CO2H). LC-MS (m/z): 310 [M]+, 308 [M]−. Purity (LC-MS): 98%.

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