Реакция #554568

Уравнение реакции

H2O

Benzo[b]thiophene-2-ylboronic acid

9-chlorophenanthridin

sodium carbonate

→

9-Benzothienylphenanthridine

Выход 78.0%

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   Температураby refluxing under a N2 atmosphere for 5 hours
2. 2
   Экстракцияthe mixture was extracted with chloroform
3. 3
   Сушкаby drying with sodium sulfate
4. 4
   ФильтрацияAfter filtration
5. 5
   Другоеthe filtrate was evaporated to dryness under reduced pressure
6. 6
   ДругоеThe obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.15 g, yield: 78%)

Методика

Benzo[b]thiophene-2-ylboronic acid (884 mg, 5.0 mmol) and 9-chlorophenanthridin (1.0 g, 4.8 mmol) were dissolved in tetrahydrofuran (30 ml), and palladium catalyst (160 mg, 0.14 mmol) and 2M sodium carbonate solution (20 ml) were added, followed by refluxing under a N2 atmosphere for 5 hours. The reaction solution was added to H2O and the mixture was extracted with chloroform, followed by drying with sodium sulfate. After filtration, the filtrate was evaporated to dryness under reduced pressure. The obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.15 g, yield: 78%).

Источник