Реакция #554566

Уравнение реакции

H2O

Benzo[b]thiophene-2-ylboronic acid

1-chloroisoquinoline

sodium carbonate

→

1-Benzothienylisoquinoline

Выход 79.0%

Растворители

toluene

ethanol

Условия реакции

Обработка

1. 1
   Температураby refluxing under a N2 atmosphere for 5 hours
2. 2
   Экстракцияthe mixture was extracted with chloroform
3. 3
   Сушкаby drying with sodium sulfate
4. 4
   ФильтрацияAfter filtration
5. 5
   Другоеthe filtrate was evaporated to dryness under reduced pressure
6. 6
   ДругоеThe obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.16 g, yield: 79%)

Методика

Benzo[b]thiophene-2-ylboronic acid (997 mg, 5.6 mmol) and 1-chloroisoquinoline (946 mg, 5.8 mmol) were dissolved in toluene (20 ml) and ethanol (10 ml), and palladium catalyst (220 mg, 0.19 mmol) and 2M sodium carbonate solution (20 ml) were added thereto, followed by refluxing under a N2 atmosphere for 5 hours. The reaction solution was added to H2O, and the mixture was extracted with chloroform, followed by drying with sodium sulfate. After filtration, the filtrate was evaporated to dryness under reduced pressure. The obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.16 g, yield: 79%).

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