Реакция #5538

Уравнение реакции

HCl

2-ethoxycarbonyl-5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine

NaOH

methanol

→

desired product

Выход 51.1%

2-carboxymethyl-5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine

Выход 51.1%

Растворители

methylene chloride

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   workup.DISTILLATIONthe solvent was distilled off
3. 3
   workup.ADDITIONWater was added to the residue
4. 4
   Промывкаthe resulting solid was washed with water
5. 5
   Другоеdried

Методика

To a solution of 2-ethoxycarbonyl-5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine (1.65 g, 4.62 mmoles) in methanol (5 ml) was added 1N NaOH (6.93 ml, 6.93 mmoles) and the mixture was stirred at room temperature for 2.5 hours. After the reaction mixture was washed with methylene chloride, 1N HCl (17.39 ml, 17.39 mmoles) was added thereto and the solvent was distilled off. Water was added to the residue and the resulting solid was washed with water and dried to obtain 777 mg of the desired product (51.1%, colorless solid).

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