Реакция #5529

Уравнение реакции

5-[2-(methylsulfonyloxy)ethylthio]imidazo[1,2-a]pyridine

triethylamine

methylamine methanol

→

desired product

Выход 47.1%

5-[2-(methylamino)ethylthio]imidazo[1,2-a]pyridine

Выход 47.1%

Растворители

chloroform

Условия реакции

Обработка

1. 1
   Температураat reflux for 3 hours
2. 2
   ПромывкаThe reaction solution was washed with an aqueous 3N-sodium hydroxide solution
3. 3
   Сушкаdried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONAfter the solvent was distilled off
5. 5
   Другоеthe residue was purified by column chromatography (eluent: methanol/chloroform=1:10)

Методика

A solution of 5-[2-(methylsulfonyloxy)ethylthio]imidazo[1,2-a]pyridine (2.18 g, 8 mmoles), triethylamine (2.24 ml, 16 mmoles) and a 40% methylamine-methanol solution (20 ml) in chloroform (20 ml) was heated at reflux for 3 hours. The reaction solution was washed with an aqueous 3N-sodium hydroxide solution and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was purified by column chromatography (eluent: methanol/chloroform=1:10) to obtain 781 mg of the desired product (47.1%, light brown oily product).

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