Реакция #55260

ord-d607a8c13ac3464b893b465e33927e0d

Уравнение реакции

morpholine

$CC(C)=CCC/C(C)=C/CC/C(=C\CC/C(C)=C/C(=O)O)CO$

(E,E,E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraenoic acid

triethylamine

ethyl chlorocarbonate

→

$CC(C)=CCC/C(C)=C/CC/C(=C\CC/C(C)=C/C(=O)N1CCOCC1)CO$

end product

$CC(C)=CCC/C(C)=C/CC/C(=C\CC/C(C)=C/C(=O)N1CCOCC1)CO$

4-[(E,E,E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraenoyl]morpholine

Реактанты

morpholine

$CC(C)=CCC/C(C)=C/CC/C(=C\CC/C(C)=C/C(=O)O)CO$

(E,E,E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraenoic acid

triethylamine

ethyl chlorocarbonate

Реагенты

Нет

Растворители

dichloromethane

Условия реакции

Подробные условия

See reaction.notes.procedure_details.

Обработка

1
Другоеthe reaction

Методика

Following the same manner as in Example 5, the reaction and after-treatment were conducted by using 400 mg of (E,E,E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraenoic acid, 0.16 ml of triethylamine, 0.13 ml of ethyl chlorocarbonate and 0.20 ml of morpholine in 10 ml of dichloromethane to afford 210 mg of the end product.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US04151357uspto-grants-1979_04