Реакция #55259

Уравнение реакции

(Z,E,E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraenoic acid

1-(2-aminoethyl)pyrrolidine

→

end product

(Z,E,E)-N-(2-pyrrolidinoethyl)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraenamide

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   Экстракцияthe reaction mixture was extracted with chloroform
2. 2
   ПромывкаThe chloroform layer was washed with aqueous sodium hydrogencarbonate
3. 3
   Экстракцияextracted with dilute hydrochloric acid
4. 4
   Экстракцияextracted with chloroform
5. 5
   ПромывкаThe chloroform layer was washed with water
6. 6
   Другоеdried
7. 7
   workup.DISTILLATIONthe solvent was distilled off
8. 8
   ДругоеThe residue was purified by a column chromatography

Методика

Following the same manner as in Example 9, the reaction was conducted using 1.0 g of (E,Z,E), (E,E,E), (Z,Z,E) and (Z,E,E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraenoic acid and 450 mg of 1-(2-aminoethyl)pyrrolidine in 6.0 ml of N,N-dimethylformamide and the reaction mixture was extracted with chloroform. The chloroform layer was washed with aqueous sodium hydrogencarbonate and extracted with dilute hydrochloric acid. The hydrochloric acid layer was neutralized with sodium hydrogencarbonate and extracted with chloroform. The chloroform layer was washed with water, dried and the solvent was distilled off. The residue was purified by a column chromatography using alumina (20 g) to afford 1.0 g of the end product.

Источник