Реакция #5524

Уравнение реакции

2-amino-6-chloropyridine

ethyl bromopyruvate

→

desired product

Выход 67.7%

2-ethoxycarbonyl-5-chloroimidazo[1,2-a]pyridine

Выход 67.7%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураat reflux for 4 hours
2. 2
   ДругоеAfter the solvent was removed
3. 3
   workup.ADDITIONchloroform was added to the residue, which
4. 4
   Промывкаwas washed in turn with saturated sodium bicarbonate and saturated saline
5. 5
   Сушкаdried over anhydrous magnesium sulfate
6. 6
   КонцентрированиеAfter the solvent was concentrated
7. 7
   workup.ADDITIONn-hexane was added to the mixture
8. 8
   ДругоеThen, the crystals precipitated
9. 9
   Фильтрацияwere filtered off
10. 10
    Промывкаwashed with n-hexane

Методика

A solution of 2-amino-6-chloropyridine (6.43 g, 50 mmoles) and ethyl bromopyruvate (9.75 g, 50 mmoles) in ethanol (150 ml) was heated at reflux for 4 hours. After the solvent was removed, chloroform was added to the residue, which was washed in turn with saturated sodium bicarbonate and saturated saline, and then dried over anhydrous magnesium sulfate. After the solvent was concentrated, n-hexane was added to the mixture. Then, the crystals precipitated were filtered off and washed with n-hexane to obtain 7.60 g of the desired product (67.6%, pale yellow crystals).

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