Реакция #5523

Уравнение реакции

(±)-6-acetyl-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

triethylamine

2,2,2-trichloroethyl chloroformate

→

1-carbamylindoline

Растворители

CH2Cl2

Условия реакции

Обработка

1. 1
   ЭкстракцияThe CH2Cl2 solution was extracted with water and 1N HCl
2. 2
   ПромывкаThe organic solution was washed with saturated NaHCO3 solution and with brine solution
3. 3
   СушкаThe CH2Cl2 solution was dried (MgSO4)
4. 4
   Концентрированиеconcentrated in vacuo

Методика

To a solution of (±)-6-acetyl-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole (2.3 g, 7.7 mmol) and triethylamine (1.1 ml, 8 mmol) in 90 ml CH2Cl2 under N2 was added dropwise a solution of 2,2,2-trichloroethyl chloroformate. The reaction mixture was stirred at RT for 1 hr. The CH2Cl2 solution was extracted with water and 1N HCl. The organic solution was washed with saturated NaHCO3 solution and with brine solution. The CH2Cl2 solution was dried (MgSO4) and concentrated in vacuo to give 3.3 g of the 1-carbamylindoline.

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