Реакция #551142

Уравнение реакции

2-amino-4-hydroxy-6-methyl-pyrimidine

chlorotrifluoroethylene

potassium hydroxide

dimethylformamide

→

2-amino-4-methyl-6-(1,1,2-trifluoro-2-chloro-ethoxy)-pyrimidine

Выход 18.0%

Растворители

methylene chloride

water

Условия реакции

Обработка

1. 1
   Экстракцияextracted with ethyl acetate
2. 2
   Другоеthe extract is evaporated
3. 3
   Другоеto give a dark oil
4. 4
   Другоеthe crystalline precipitate formed
5. 5
   Другоеis separated off

Методика

25 g of 2-amino-4-hydroxy-6-methyl-pyrimidine, 25.6 g of chlorotrifluoroethylene, 13.8 g of potassium hydroxide and 200 ml of dimethylformamide are stirred together at 60° in an autoclave for 8 hours. The mixture is diluted with water and extracted with ethyl acetate and the extract is evaporated to give a dark oil. A little methylene chloride is added and the crystalline precipitate formed is separated off to give 8.7 g of 2-amino-4-methyl-6-(1,1,2-trifluoro-2-chloro-ethoxy)-pyrimidine of melting point 73°-74° C.

Источник