Реакция #5510

Уравнение реакции

t-Butyl methyl 7-bromoheptylmalonate

Sodium iodide

→

t-butyl methyl 7-iodoheptylmalonate

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураat reflux for 2 hours
2. 2
   ФильтрацияThe reaction mixture is filtered
3. 3
   Концентрированиеthe filtrate is concentrated to dryness
4. 4
   workup.DISSOLUTIONThe residue is dissolved in methylene chloride
5. 5
   Фильтрацияfiltered again
6. 6
   КонцентрированиеThe filtrate is concentrated to dryness

Методика

t-Butyl methyl 7-bromoheptylmalonate (8.81 g, 25.1 mmol) is dissolved in acetone (50 ml). Sodium iodide (3.7 g, 25.1 mmol) is added and the mixture is stirred at reflux for 2 hours. The reaction mixture is filtered and the filtrate is concentrated to dryness. The residue is dissolved in methylene chloride and filtered again. The filtrate is concentrated to dryness to give t-butyl methyl 7-iodoheptylmalonate as an oil.

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