Реакция #55094

Уравнение реакции

hydroxylamine hydrochloride

sodium

ethyl α-naphthylcarbamoylacetate

hydroxylamine

→

α-Naphthylcarbamoylacetohydroxamic acid

Выход 62.0%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ДругоеAfter leaving the reactants in contact for 5 hours
2. 2
   Другоеthe mixture is evaporated to dryness in vacuo
3. 3
   Фильтрацияthe solution is filtered over charcoal
4. 4
   Другоеthe product is precipitated cold with 3 N HCl
5. 5
   Фильтрацияfiltered off
6. 6
   Промывкаwashed with water
7. 7
   ДругоеCRL 40,518 is obtained by recrystallisation from ethanol

Методика

19.3 g (0.075 mol) of ethyl α-naphthylcarbamoylacetate are treated with a solution of hydroxylamine, prepared from 5.6 g (0.08 mol) of hydroxylamine hydrochloride and 3.68 g of sodium in 250 ml of methanol. After leaving the reactants in contact for 5 hours, the mixture is evaporated to dryness in vacuo, the residue is taken up in 400 ml of cold water, the solution is filtered over charcoal, and the product is precipitated cold with 3 N HCl, filtered off and washed with water. CRL 40,518 is obtained by recrystallisation from ethanol. Yield: 62%. Melting point: 184°-186° C. (with decomposition).

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