Реакция #549352

Уравнение реакции

K2CO3

2-cyanothiophene

hydroxylamine HCl

→

product

Выход 80.0%

2-Thiopheneamidoxime

Выход 80.0%

Растворители

water

water

ethanol

Условия реакции

Обработка

1. 1
   ТемператураThe mixture is refluxed for 16 hours
2. 2
   Температураcooled
3. 3
   ДругоеAfter removing the ethanol in vacuo
4. 4
   Другоеthe product precipitates out of the aqueous residue
5. 5
   ФильтрацияIt is collected by filtration
6. 6
   Промывкаwashed with water
7. 7
   Другоеdried

Методика

To a solution of 21.8 g (0.20 mole) of 2-cyanothiophene in 500 ml of ethanol, 13.9 g (0.20 mole) of hydroxylamine HCl is added, followed by the addition of 13.8 g (0.10 mole) of K2CO3 in 50 ml of water. The mixture is refluxed for 16 hours, cooled and diluted with 200 ml of water. After removing the ethanol in vacuo, the product precipitates out of the aqueous residue. It is collected by filtration, washed with water and dried to yield 22.4 g (80%) of product, m.p. 70°-75°.

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