Реакция #548402

Уравнение реакции

methylchloroacetate

3-mercapto-2,6-dimethyl-4-heptanone

sodium methoxide

H2SO4

→

3-[(METHOXYCARBONYL)METHYLTHIO]-2,6-DIMETHYL-4-HEPTANONE

Растворители

methanol

methanol

water

Условия реакции

Обработка

1. 1
   ДругоеInto a 50 ml, round-bottom, three-necked flask equipped with magnetic stirrer
2. 2
   workup.STIRRINGAfter stirring 8 minutes
3. 3
   Другоеrising to 38° C
4. 4
   workup.STIRRINGis stirred for a period of 2 hours

Методика

Into a 50 ml, round-bottom, three-necked flask equipped with magnetic stirrer, pot thermometer, "Y" tube, nitrogen inlet tube, reflux condenser with cotton plug, H2SO4 bubbler for nitrogen, and cold water bath is added a solution of 0.65 grams of sodium methoxide dissolved in 10 ml anhydrous methanol. At a reaction mass temperature of 25°-28° C and over a period of one minute, with stirring, is added a solution of 2.1 grams of 3-mercapto-2,6-dimethyl-4-heptanone dissolved in 2 ml anhydrous methanol. After stirring 8 minutes, 1.30 grams of methylchloroacetate (0.012 moles) is added over a period of 2 minutes, to the reaction mass; the temperature of the reaction mass rising to 38° C. The reaction mass is allowed to cool to 24° C and is stirred for a period of 2 hours.

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