Реакция #54689

Уравнение реакции

dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide

piperidine

→

dimethyl 6-piperidino-2,4-pyrimidine-dicarbamate-3-oxide

Растворители

methylene chloride

Условия реакции

Обработка

1. 1
   workup.ADDITIONA suspension of 7.5 g
2. 2
   ДругоеThe white precipitate formed
3. 3
   Фильтрацияis filtered off
4. 4
   Другоеrecrystallized from a mixture of methylene chloride and methanol, there

Методика

A suspension of 7.5 g. of dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide in 35 ml. of methylene chloride is treated with 14.5 ml. of piperidine and the mixture is stirred at room temperature under an argon atmosphere for 18 hours. The white precipitate formed is filtered off and recrystallized from a mixture of methylene chloride and methanol, there being obtained pure dimethyl 6-piperidino-2,4-pyrimidine-dicarbamate-3-oxide, having a melting point of 202° C. (decomposition).

Источник