Реакция #54664

Уравнение реакции

p-menth-3-oyl chloride

ethanolamine

→

N-(2-hydroxyethyl)-p-menthane-3-carboxamide

Растворители

chloroform

chloroform

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture becomes warm
2. 2
   Другоеfinally a yellow oil starts to separate out
3. 3
   workup.ADDITIONwas poured into water
4. 4
   ДругоеThe organic layer was separated
5. 5
   Промывкаwashed with dilute H2SO4
6. 6
   Сушкаdried (MgSO4)
7. 7
   ДругоеRemoval of the solvent
8. 8
   workup.WAITleft a viscous oil (3.8 g.)
9. 9
   workup.DISTILLATIONThis was distilled under vacuum

Методика

A solution of p-menth-3-oyl chloride prepared as in Example 1 (4.0g., 0.020 moles) in chloroform (30 ml.) was added dropwise to a stirred solution of ethanolamine (3 g., 0.043 moles) in chloroform (50 ml.). The reaction mixture becomes warm, goes cloudy and finally a yellow oil starts to separate out. After stirring for 2 hours at room temperature the mixture was poured into water. The organic layer was separated, washed with dilute H2SO4, and dried (MgSO4). Removal of the solvent left a viscous oil (3.8 g.). This was distilled under vacuum to yield N-(2-hydroxyethyl)-p-menthane-3-carboxamide as a colourless very viscous oil, b.p. 160°/01. mm.

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