Реакция #54663

Уравнение реакции

p-menth-3-oyl chloride

Sodium bicarbonate

glycine ethyl ester hydrochloride

→

N-p-menth-3-oylglycine ethyl ester

Растворители

ether

water

Условия реакции

Обработка

1. 1
   ДругоеAt the end of this time the ether layer was separated
2. 2
   Сушкаdried (MgSO4)
3. 3
   ДругоеRemoval of the solvent
4. 4
   workup.WAITleft an oily solid (12.3 g.)
5. 5
   workup.DISTILLATIONThis was distilled under reduced pressure

Методика

Sodium bicarbonate (8.4 g., 0.1 mole) and glycine ethyl ester hydrochloride (7 g. 0.05 mole) were dissolved in water (100 ml.), and a solution of p-menth-3-oyl chloride (10 g., 0.05 mole) in ether (50 ml.) was added and the mixture stirred vigorously at room temperature for 2 hours. At the end of this time the ether layer was separated and dried (MgSO4). Removal of the solvent left an oily solid (12.3 g.). This was distilled under reduced pressure to yield N-p-menth-3-oylglycine ethyl ester, bp. 150- 2°/0.1 mm. as a colourless liquid which rapidly solidified.

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