Реакция #54652

Уравнение реакции

DDQ

2,3-dihydro-6-hydroxy-7-methoxy-5-benzofuran-carboxaldehyde

→

6-Hydroxy-7-methoxy-5-benzofurancarboxaldehyde

Растворители

dioxane

dioxane

Условия реакции

Обработка

1. 1
   Температураunder reflux for 7 hours
2. 2
   Температураcooled
3. 3
   Другоеthe formed solid removed by filtration
4. 4
   ПромывкаThe precipitate was thoroughly washed first with benzene
5. 5
   Концентрированиеthe total concentrated in vacuo to a residue which
6. 6
   Другоеwas chromatographed first on a 20 ml
7. 7
   Промывкаdry silica gel column (E. Merck 7734) with CHCl3 elution
8. 8
   Промывкаelution with this solvent mixture
9. 9
   Другоеprovided

Методика

A solution of 817 mg. (3.6 mmole) of DDQ in 10 ml. of dioxane was added to 582 mg. (3 mmole) of 2,3-dihydro-6-hydroxy-7-methoxy-5-benzofuran-carboxaldehyde in 15 ml. of dioxane and the resulting mixture was heated under reflux for 7 hours, cooled and the formed solid removed by filtration. The precipitate was thoroughly washed first with benzene, then with CHCl3. The washings were combined with the initial filtrate and the total concentrated in vacuo to a residue which was chromatographed first on a 20 ml. dry silica gel column (E. Merck 7734) with CHCl3 elution followed by conventional chromatography over 20 g. of silica (E. Merck 7734) packed in benzene-ethyl acetate (95:5) and elution with this solvent mixture provided, after workup, a yellow solid, m.p. 60°-62°.

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