Реакция #54602

Уравнение реакции

7-amino-7-methoxy-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

triethylamine

2-(1-Pyrryl)propanedioic acid, 3-ethyl ester

triethylamine

iso-butyl chloroformate

→

7-[[2-Carboethoxy-2-(1-pyrryl)acetyl]amino]-7-methoxy-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Растворители

THF

tetrahydrofuran

Условия реакции

Обработка

1. 1
   Температураthe temperature is maintained at 0° C. for about 15 minutes
2. 2
   workup.STIRRINGwith stirring to the previous solution

Методика

2-(1-Pyrryl)propanedioic acid, 3-ethyl ester, 1 equivalent and 1 equivalent of triethylamine is added to tetrahydrofuran (THF) which is cooled to 0° C. While stirring, iso-butyl chloroformate, 1 equivalent, is added and the temperature is maintained at 0° C. for about 15 minutes. A cold solution of 7-amino-7-methoxy-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 1 equivalent, and triethylamine, 1 equivalent, in 50% aqueous THF is added with stirring to the previous solution.

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