Реакция #54592

Уравнение реакции

2-Aminopentanoic acid

sodium acetate

2.5-dimethoxytetrahydrofuran

→

2-(1-pyrryl)pentanoic acid

Растворители

acetic acid

acetic acid

Условия реакции

Обработка

1. 1
   ТемператураThis solution is heated
2. 2
   Температураis then refluxed for 5 minutes
3. 3
   ТемператураThe mixture is refluxed for a further 2 minutes
4. 4
   Другоеevaporated
5. 5
   Промывкаwashed with water
6. 6
   Другоеdried
7. 7
   Другоеthe solvent removed under vacuo

Методика

2-Aminopentanoic acid (0.2 mole) is added to a solution of sodium acetate (0.2 mole) in about 300 ml of glacial acetic acid. This solution is heated to effect solution and is then refluxed for 5 minutes. To the refluxing solution is added (0.2 mole) 2.5-dimethoxytetrahydrofuran as quickly as possible. The mixture is refluxed for a further 2 minutes and the acetic acid is flash evaporated. The residue is taken up in ethyl acetate, washed with water, dried and the solvent removed under vacuo to give 2-(1-pyrryl)pentanoic acid.

Источник