Реакция #54591

Уравнение реакции

water

Chloroform

potassium phthalimide

ethyl-2-bromopentanoate

→

ethyl α-phthalimidopentanoate

Растворители

DMF

dimethylformamide

Условия реакции

Обработка

1. 1
   ДругоеThe phases are separated
2. 2
   Экстракцияthe aqueous phase is extracted with chloroform
3. 3
   Экстракцияextracted with 0.1 N sodium hydroxide and with water
4. 4
   СушкаAfter drying over sodium sulfate
5. 5
   Другоеthe chloroform is removed

Методика

To a solution of potassium phthalimide (0.1 mole) in about 50 ml of dimethylformamide (DMF) is added 1 equivalent of ethyl-2-bromopentanoate. The temperature is maintained at about 60° C. for 10 minutes. Chloroform is added to the cooled DMF solution and the mixture is poured into water. The phases are separated and the aqueous phase is extracted with chloroform. The chloroform extracts are combined, extracted with 0.1 N sodium hydroxide and with water. After drying over sodium sulfate, the chloroform is removed to give ethyl α-phthalimidopentanoate.

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