Реакция #54511

Уравнение реакции

1-(5-chloro-1-hydroxynaphthalen-2-yl)-1-dodecanone

hydrochloric acid

hydrochloric acid

→

5-chloro-2-dodecyl-1-naphthalenol

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Промывкаby washing with ethanol
2. 2
   workup.ADDITIONThe zinc amalgam was added in small portions throughout the reaction period
3. 3
   ТемператураUpon cooling
4. 4
   Другоеa solid separated
5. 5
   workup.DISSOLUTIONAfter dissolution of this solid in ethanol
6. 6
   Фильтрацияzinc amalgam was filtered
7. 7
   Температураcooling
8. 8
   Другоеgave 0.5 parts of starting material which
9. 9
   Фильтрацияwas filtered
10. 10
    ДругоеConcentration of the filtrate, purification
11. 11
    Другоеby recrystallization from ethanol, and column chromatography on silica gel

Методика

A solution of 17.4 parts of 1-(5-chloro-1-hydroxynaphthalen-2-yl)-1-dodecanone and 107 parts of 37% hydrochloric acid in 2.5 parts of ethanol was contacted with stirring at reflux during 26 hours, with 40 parts of zinc dust which has been amalgamated by treatment with 3 parts of mercuric chloride and 53 parts of 2.1% hydrochloric acid followed by washing with ethanol. The zinc amalgam was added in small portions throughout the reaction period. Upon cooling, a solid separated. After dissolution of this solid in ethanol, zinc amalgam was filtered, and cooling gave 0.5 parts of starting material which was filtered. Concentration of the filtrate, purification by recrystallization from ethanol, and column chromatography on silica gel using 1-chlorobutane as eluent gave 12 parts of 5-chloro-2-dodecyl-1-naphthalenol, m.p. 68°-70° C.

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