Реакция #54507

Уравнение реакции

ethyl 4-(2-methylphenyl)-3-oxobutanoate

sodium methoxide

1-bromododecane

potassium iodide

→

ethyl 2-[(2-methylphenyl)acetyl]tetradecanoate

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ДругоеThe mixture was evaporated to a small volume
2. 2
   workup.ADDITIONdiluted with 100 parts water
3. 3
   Экстракцияextracted with ether
4. 4
   ЭкстракцияThe ether extract
5. 5
   Промывкаwas washed with saturated sodium bicarbonate, saturated sodium chloride solution
6. 6
   Сушкаdried over magnesium sulfate
7. 7
   ДругоеEvaporation of the ether

Методика

Three parts of ethyl 4-(2-methylphenyl)-3-oxobutanoate, 1 part of sodium methoxide, 4.6 parts of 1-bromododecane, 0.5 parts of potassium iodide and 50 parts of absolute ethanol were refluxed together for 4 hours and then stirred 18 hours at room temperature. The mixture was evaporated to a small volume, diluted with 100 parts water and extracted with ether. The ether extract was washed with saturated sodium bicarbonate, saturated sodium chloride solution and dried over magnesium sulfate. Evaporation of the ether gave 6 parts of crude ethyl 2-[(2-methylphenyl)acetyl]tetradecanoate as an oil which was not further purified.

Источник