Реакция #54461

Уравнение реакции

lithium amide

methyl t-butylsulphonyl-acetate

4-hydroxy-2,2,6,6-tetramethylpiperidine

→

2,2,6,6-tetramethyl-4-piperidinyl t-butyl-sulphonyl-acetate

Растворители

xylene

xylene

Условия реакции

Обработка

1. 1
   ТемператураThe mixture is warmed to 130°
2. 2
   ДругоеThe xylene is removed in vacuo
3. 3
   workup.DISTILLATIONthe residue is distilled

Методика

38.8 g (0.2 mol) of methyl t-butylsulphonyl-acetate, prepared according to the method of von Leusen and Strating, Rec. Trav, Chim. 84, 140 (1965), and 31.4 g (0.2 mol) of 4-hydroxy-2,2,6,6-tetramethylpiperidine are dissolved in 50 ml of xylene. The mixture is warmed to 130°, 0.2 g of lithium amide in 50 ml of xylene is added and the mixture is stirred for 12 hours at 130°-140°. The xylene is removed in vacuo and the residue is distilled to give 2,2,6,6-tetramethyl-4-piperidinyl t-butyl-sulphonyl-acetate; yield: 33.7 grams, boiling point 153°-154°/10-3 mm Hg.

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